Transplantable osteogenic sarcoma in inbred AKR mice.

Spontaneous transplantable osteogenic sarcoma in mice is rare. Heiple et al. (6) have described an osteogenic sarcoma in C3H/Hes mice, which was maintained by serial subcutaneous transfer for over 100 transplant generations. Craig et al. (2) reported an osteogenic sarcoma arising in an aduk SpragueDawley rat; the tumor was successfully transplanted into Holtzman rats, and it retained its bone-producing capacity up to the 8th generation. Pybus and Miller (9, 10) described a subline of inbred mice derived from the Sympson stock which developed a high incidence of osteosarcomas and other bone tumors. However, spontaneous osteogenic sarcomas which are transplantable and retain the capability of bone production have not been described in inbred mice. In the present communication, we describe a spontaneous osteogenic sarcoma in the AKR inbred mouse. This tumor has been transplanted for 44 generations and has retained its original histologic differentiation pattern.